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METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP)
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DeCS
Descriptor
English
:
Methylenetetrahydrofolate Dehydrogenase (NADP)
Descriptor
Spanish
:
Metilenotetrahidrofolato Deshidrogenasa (NADP)
Descriptor
Portuguese
:
Metilenotetraidrofolato Desidrogenase (NADP)
Synonyms
English
:
Methylenetetrahydrofolate Dehydrogenase (NADP+)
Tree Number:
D08.811.682.662.253
Definition
English
:
An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional
METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE
and
FORMATE-TETRAHYDROFOLATE LIGASE
activity. The enzyme plays an important
role
in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of
HOMOCYSTEINE
to
METHIONINE
via
METHIONINE
SYNTHETASE.
Indexing Annotation
English
:
do not confuse with
METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD+)
See Related
English
:
Formate-Tetrahydrofolate Ligase
Methenyltetrahydrofolate Cyclohydrolase
History Note
English
:
2004(1975);
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
8940
Unique Identifier:
D008754
Occurrence in VHL
:
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